Thermo Fisher Scientific ACVR2B Polyclonal Antibody
Human ACVR2B 단백질을 인식하는 goat polyclonal antibody로, WB, IHC(P), Flow Cytometry 등에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 4°C 단기 보관 및 -20°C 장기 보관 권장. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 0.1–0.2 µg/mL | |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | |
| Flow Cytometry (Flow) | 10 µL for 1–2.5 × 10⁵ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment of human Activin Receptor Type IIB |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2222466 |
Product Specific Information
Neutralization: When used at 1–3 µg/mL, this antibody blocks approximately 50% of the binding of 30 ng/mL recombinant human activin A to immobilized recombinant human activin receptor IIB/Fc chimera (100 µL of a 0.5 µg/mL solution coating each well) in an ELISA assay.
Target Information
ACVR2B is a type II receptor in the TGF-beta family of serine/threonine kinases and is involved in activin and myostatin signaling pathways. Activins and inhibins belong to the TGF-beta superfamily, sharing conserved cysteine residues characteristic of this group. Multiple splice variants of activin receptor IIA and IIB have been identified in mammals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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