Thermo Fisher Scientific CYLD Polyclonal Antibody
CYLD 단백질을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에 반응합니다. Western Blot 및 IHC(Paraffin) 실험에 적합하며, 고순도 Affinity Chromatography로 정제된 액상 제품입니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CYLD (Accession Q9NQC7), corresponding to amino acid residues V876–L926 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2854002 |
Product Specific Information
Antibody detects endogenous levels of total CYLD.
Target Information
CYLD is a 956 amino acid cytoplasmic deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family. It contains three CAP-GLY domains, a proline-rich region, a SH3 binding domain, and a catalytic domain homologous to UCH. CYLD acts as a tumor suppressor protein and negatively regulates TRAF2 and NF-κB signaling pathways. It also regulates the I-κB kinase pathway and deubiquitinates non-Lys-48-linked polyubiquitin chains. Mutations in CYLD are associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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