Thermo Fisher Scientific RANBP1 Polyclonal Antibody
Human 및 Mouse 시료에서 RanBP1 단백질 검출용 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합. 합성 펩타이드 기반 항원으로 특이적 결합. 항원 친화 크로마토그래피로 정제된 액상 형태. 연구용 전용 제품.
- 카탈로그번호
- PA1080
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:5,000 | - |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues M(1) A A A K D T H E D H D T S T E N T(18) C of human RanBP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_325804 |
Product Specific Information
PA1-080 detects Ran binding protein 1 (RanBP1) from human and mouse cells.
It has been successfully used in Western blot procedures, detecting an approximately 30 kDa protein representing RanBP1 from HeLa cell extract.
The immunogen is a synthetic peptide corresponding to residues M(1) A A A K D T H E D H D T S T E N T(18) C of human RanBP1.
The immunizing peptide (Cat. # PEP-128) is available for use in neutralization and control experiments.
Target Information
Ran/TC4-binding protein (RanBP1) interacts specifically with GTP-charged RAN.
RANBP1 encodes a 23-kDa protein that binds to RAN complexed with GTP but not GDP.
It does not activate GTPase activity of RAN but markedly increases GTP hydrolysis by RanGTPase-activating protein (RanGAP1).
The RANBP1 cDNA encodes a 201-amino acid protein that shows 92% similarity to its mouse homolog.
In both mammalian cells and yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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