Thermo Fisher Scientific PRTFDC1 Polyclonal Antibody
Thermo Fisher Scientific PRTFDC1 Polyclonal Antibody는 인간 및 랫트 반응성을 가진 Rabbit IgG 항체로, Western blot에 적합합니다. PBS 버퍼에 보존되며 1 mg/mL 농도로 제공됩니다. PRTFDC1 단백질 연구 및 종양 억제 관련 연구에 활용됩니다.
- 카탈로그번호
- PA520593
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide from near the center of human PRTFDC1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155790 |
Product Specific Information
- Suggested positive control: human brain tissue lysate
- PA5-20593 can be used with blocking peptide PEP-0713.
Target Information
Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event. CpG islands in the PRTFDC1 promoter can be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibits cell growth, while knockdown promotes growth, suggesting PRTFDC1 acts as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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