Thermo Fisher Scientific GP6 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• A suggested positive control is A-20 cell lysate.
• PA5-20582 can be used with blocking peptide PEP-0702.

Target Information

Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in platelet deposition. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels.
Platelet interaction with collagen occurs as a two-step process:

1. Initial adhesion to collagen
2. Activation leading to platelet secretion, recruitment of additional platelets, and aggregation

Under physiological conditions, the resulting platelet plug serves as the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.