Thermo Fisher Scientific Calpain 6 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• A suggested positive control is rat lung tissue lysate.
• PA5-20592 can be used with blocking peptide PEP-0712.

Target Information

Calpain-6 (also known as calpamodulin or calpain-X) is an intracellular, calcium-dependent cysteine protease. It shows tissue-specific expression in adults, mainly in the placenta, and embryonically in several tissues.
Classical calpains consist of a common small subunit (calpain-4) and a large variable subunit, but it is not known if calpain-6 associates with a small subunit. The large subunit includes domain-I (amino terminal), domain-II (proteinase), domain-III, and domain-IV (EF-hand domain).
Calpain-6, located on the X chromosome, lacks the EF-hand calcium-binding motif found in domain-IV of classical calpains. The active site residues Cys, His, and Asn are replaced by Lys, His, and Asn in human, and Lys, Tyr, and Asn in mouse calpain-6, suggesting that it is unlikely to be proteolytically active.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.