Thermo Fisher Scientific CD2 Recombinant Rat Monoclonal Antibody (YTH 655)

Applications

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent

Functional Assay (Functional)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

This antibody specifically recognizes human CD2, a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells.

Target Information

CD2 (LFA-2) is a monomeric surface antigen (MW range 45–58 kDa) of the human T-lymphocyte lineage, expressed on most peripheral blood T cells and some NK cells, but not on B lymphocytes.
Monoclonal antibodies against CD2 inhibit rosette formation with sheep erythrocytes, indicating its role as the erythrocyte receptor or its close association with it.
CD2 interacts with CD58 to stabilize adhesion between T cells and antigen-presenting or target cells. Although the affinity between CD2 and CD58 is relatively low in solution, it is strengthened at the cell-cell interface.
T cell activation increases CD2 expression and mobility, facilitating CD2-CD58 interactions and enhancing intercellular adhesion.
CD2 deficiency reduces intestinal inflammation and helps control infection. Diseases associated with CD2 dysfunction include penis squamous cell carcinoma and immune deficiency due to thymus absence.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.