Thermo Fisher Scientific CD205 Recombinant Rat Monoclonal Antibody (NLDC145)
CD205(DEC-205)에 특이적인 랫트 단클론 항체로, 마우스 시료에 반응. WB, IHC, ICC, Flow Cytometry 등 다양한 응용에 사용 가능. Protein A 정제, 1 mg/mL 농도, PBS buffer에 ProClin 300 포함. 항원 섭취 연구 및 수지상세포 표지에 적합.
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Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (IHC): Assay-dependent
- Immunocytochemistry (ICC/IF): Assay-dependent
- Flow Cytometry (Flow): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | NLDC145 |
| Immunogen | This antibody was raised by immunising Wistar rats with mouse lymph node stroma. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody is specific for murine DEC-205, a lectin endocytic receptor expressed at high levels by many dendritic cell subsets, where it mediates antigen uptake. The epitope recognised by this antibody is trypsin-sensitive.
Target Information
CD205 (LY25, Lymphocyte Antigen 75) is an integral membrane glycoprotein involved in antigen uptake, trafficking, and presentation that improves the induction of antigen-specific T cell immunity.
CD205 is highly expressed by CD8+ dendritic cells (DCs) and also expressed at different levels by bone marrow Gr1+ cells, Langerhans cells, bone marrow-derived DCs (BMDCs), and thymic epithelial cells.
CD205 acts as an endocytic receptor that directs captured antigens to a specialized antigen processing region and can reduce B lymphocyte proliferation.
Diseases associated with CD205 dysfunction include pneumonic plague and lipid pneumonia.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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