Thermo Fisher Scientific SMN1 Monoclonal Antibody (2F1)
SMN1 단백질을 검출하는 Thermo Fisher Scientific의 Mouse IgG1 단클론 항체. Western blot, IHC, Flow cytometry, ELISA 등 다양한 응용에 사용 가능. 인간 및 비인간 영장류 반응성. 장기 보관 시 -20°C에서 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2F1 |
| Immunogen | Purified recombinant fragment of human SMN1 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11155770 |
Product Specific Information
MA5-15857 targets SMN1 in indirect ELISA, FACS, IHC, and WB applications and shows reactivity with Human and Non-human primate samples.
The immunogen is a purified recombinant fragment of human SMN1 expressed in E. coli.
MA5-15857 detects SMN1, which has a predicted molecular weight of approximately 39 kDa.
Target Information
The SMN1 gene is part of a 500 kb inverted duplication on chromosome 5q13. This region contains multiple genes and repetitive elements, making it prone to rearrangements and deletions. The telomeric and centromeric copies encode the same protein — survival motor neuron protein.
The SMN complex plays a catalytic role in the assembly of small nuclear ribonucleoproteins (snRNPs), essential components of the spliceosome. Mutations in the SMN1 gene are known to cause spinal muscular atrophy types 1 and 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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