Thermo Fisher Scientific CDK9 Monoclonal Antibody (1B5A7)
인간 CDK9 단백질을 인식하는 Mouse IgG1 단클론 항체로, WB, IHC, ELISA에 적합합니다. 비결합형 액상 형태이며, CDK9의 약 43kDa 단백질을 검출합니다. 세포주기 및 전사 조절 연구용으로 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B5A7 |
| Immunogen | Purified recombinant fragment of human CDK9 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11152362 |
Product Specific Information
MA5-15849 targets CDK9 in indirect ELISA, IHC, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human CDK9 expressed in E. coli.
MA5-15849 detects CDK9, which has a predicted molecular weight of approximately 43 kDa.
Target Information
CDK9 is a serine/threonine kinase that forms an active holoenzyme complex with Cyclin T1, playing a key role in regulating the eukaryotic cell cycle. It is coexpressed and copurified with Cyclin T1 and regulates cytokine-inducible transcription networks by facilitating promoter recognition of target transcription factors.
CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity toward the CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and predisposition to heart failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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