Servicebio Tissue Homogenizer Low-temperature (-40℃)

Product IntroductionKZ-Ⅲ-FPLow temperature tissue homogenizer (-40℃) can reach a low temperature environment of -40 °C. It uses a vertical oscillation system to reciprocate at high speed to make the frozen sample in the grinding tube collide with the grinding beads. The tissue is completely broken, and it is a special equipment for one-time rapid processing of multiple samples in research institutes, universities, agricultural institutes, biomedicine, food testing and other fields.

Traditional mortar grinding can only grind one sample at a time, and the processing efficiency is low; and tools such as the mortar must be cleaned and sterilized each time, which greatly increases the workload of sample processing.

Low Temperature Homogenizer Sample Grinding -40℃ can greatly improve sample processing:

1. Dry grinding, wet grinding and homogenization of samples can be performed;

2. It can process up to 24 samples at the same time (upgradable to process 60 samples at the same time), and complete the sample preparation in a fast and high-throughput manner;

3. Can be replaced with different capacity adapters 0.5ml, 2ml, 5ml, 10ml, 50ml;

4. Wide range of samples that can be processed:

a. Suitable for grinding and crushing of various plant tissues including roots, stems, leaves, flowers, fruits, seeds and other samples;

b. Suitable for grinding and crushing of various animal tissues including brain, heart, lung, stomach, liver, thymus, kidney, intestine, lymph node, muscle, bone and other samples;

c. Grinding and crushing suitable for the analysis and detection of food and drug components;

5. A closed disposable centrifuge tube is used, which can effectively avoid cross-contamination between samples;

6. The experiment has strong repeatability, and the same grinding frequency and time can be set to obtain the same grinding effect;

7. Refrigeration function: -40℃ to room temperature; Temperature control accuracy: ±1℃.

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Product Features

1. Slider drive, no wear shaft, noise stability and durability;

2. Minimum refrigeration temperature -40 ℃, the whole process of low-temperature grinding, reduce protein and RNA degradation;

3. Up to 60 samples can be processed simultaneously in 1 min (24 samples come standard);

4. A variety of adapters to choose from.

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Technical Parameters

1. It can process up to 24 samples at the same time in 1 minute (upgrade to process 60 samples at the same time), and complete the sample grinding quickly, efficiently and with high throughput;

2. Large touch screen design, easy to operate, and 10 groups of common tissue grinding parameters (plant stem and leaf, tissue heart, liver, spleen, lung and kidney, skin, bone, etc.) are preset to optimize the grinding conditions of different specimens;

3. Noise level: <65db;

4. Maximum feed size: no requirement, adjusted according to the adapter;

5. Emergency stop button: It can be photographed at any time during the grinding process, and the instrument will stop running, which is fast and safe;

6. Rapid cooling: cool down to below zero in a short time after starting to prevent degradation, temperature range: -40°C - room temperature;

7. Electromagnetic safety lock: the electromagnetic lock cannot open the cover during the working process, until the end of the grinding process, and the whole process is protected;

8. Grinding method: wet grinding, dry grinding, low temperature grinding;

9. Provide no less than 60 SCI cited papers as experimental guidance

10. Using a special three-dimensional vibration mode of up and down and left and right shaking, the grinding is more sufficient and the stability is better;

10. An optional 60-hole adapter can be installed, which can be upgraded to grind 60 samples each time, further improving the grinding efficiency.

11. Different adapters can be selected to match different requirements for sample grinding: 24*0.5ml; 48*2ml; 32*2ml; 60*2ml; 12*5ml; 10*10ml; 4*30ml; 2*50ml (also according to Customized according to actual needs)

12. Dimensions: 500*365*370mm

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Parameter Setting and Grinding Bead Reference

1) Protein Extraction

Product Name	Grinding Beads	Frequency	Grinding Time	Pause Time	Cycle times	Recommended** Extraction Solution**
Plant Stems, Leaves	Stainless Steel Beads 3mm*3, 4mm*1	60Hz	60s	15s	3	Protein Extraction Solution
Heart, Liver, Spleen, Lungs, Kidneys, Brain of Mice and Rats	Stainless Steel Beads 3mm*2, 4mm*1	60Hz	30s	15s	2	Protein Extraction Solution
Stomach, Intestines, Muscles, Fat, Pancreas of Mice and Rats	Stainless Steel Beads 3mm*2, 4mm*1	60Hz	45s	15s	2	Protein Extraction Solution
Skin, Ears, Tail, Blood Vessels of Mice and Rats	Stainless Steel Beads 3mm*3, 4mm*2	70Hz	60s	20s	3	Protein Extraction Solution
Cartilage, Hair, Hard Bones of Mice and Rats	Stainless Steel Beads 3mm*4, 4mm*2	70Hz	90s	20s	3	Protein Extraction Solution
(This condition is for reference only, and can be adjusted at any time during the experiment according to the grinding effect.)

2) RNA Extraction

Product Name	Grinding Beads	Frequency	Grinding Time	Pause Time	Cycle times	Recommended Extraction Solution
Plant Stems, Leaves	Zirconia Beads 3mm*3, 4mm*1	60Hz	60s	15s	3	RNA Extraction Solution
Heart, Liver, Spleen, Lungs, Kidneys, Brain of Mice and Rats	Zirconia Beads Beads 3mm*2, 4mm*1	60Hz	30s	15s	2	RNA Extraction Solution
Stomach, Intestines, Muscles, Fat, Pancreas of Mice and Rats	Zirconia Beads Beads 3mm*3, 4mm*2	60Hz	45s	15s	2	RNA Extraction Solution
Skin, Ears, Tail, Blood Vessels of Mice and Rats	Zirconia Beads Beads 3mm*4, 4mm*2	70Hz	60s	20s	3	RNA Extraction Solution
Cartilage, Hair, Hard Bones of Mice and Rats	Zirconia Beads Beads 3mm*3, 4mm*4	70Hz	90s	20s	3	RNA Extraction Solution
(This condition is for reference only, and can be adjusted at any time during the experiment according to the grinding effect.)

For RNA extraction, the grinding time is extended compared with that of protein extraction, and RNA extraction solution is added to the grinding, the specific grinding time depends on the amount and type of tissue to be ground. Samples difficult to break can be repeated grinding 2-3 times, the specific situation can be adjusted appropriately according to the experiment.

Strong and Tough Tissue Grinding

For samples that are difficult to grind (e.g. cartilage, hair, etc.), we recommend using a 2mL grinding tube. Cut the sample into 1-2mm pieces, add the appropriate number of grinding beads, cover the tube tightly and freeze in liquid nitrogen for 2-3min without extracting solution, dry grind for 60 seconds at 70Hz, then add extracting solution to the tube and repeat the grinding once. If the grinding result is not satisfactory, the tube can be frozen again and the above experimental steps can be repeated.

Bone Tissue Grinding

For bone tissue, use the special steel grinding jar and adapter. The bone tissue is first frozen in liquid nitrogen for 5-10min, then put into the grinding jar, add the steel beads, and grind for 180 seconds at 70Hz (set cycle grinding). After grinding, take out the finished tissue, put it into a 2mL grinding tube, add the extraction solution, two 3mm grinding beads and homogenize for 60 seconds.

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Parameters Comparison

Cat. No.	KZ-III	KZ-III-F/FP	KZ-5F-3D	SWE-FP
Operating mode	Vertical oscillation system with high-speed reciprocating motion	Vertical oscillation system with high-speed reciprocating motion	Presents a 3D ∞ shaped motion in space	Vertical oscillation system with high-speed reciprocating motion
Temperature	Room temperature	-10℃/-40℃	-40℃	-50℃
Temperature control precision	N/A	±1℃	±1℃	±1℃
Standard spec.	24*2 mL	24*2 mL	24*2 mL	24*2 mL
Maximum sample volume	60 pcs	60 pcs	24 pcs	192 pcs
Adapter specification	0.5 mL×24; 2 mL×24; 2 mL×24; 2 mL×32; 2 mL×48; 2 mL×48; 2 mL×60; 5 mL×12; 10 mL×10; steel can 5mL×6; steel can 15 mL×8; steel can 30 mL×4; steel can 50 mL×2; PTFE 30mL×4; PTFE 50 mL×2		3D 2mL×24; 3D 5mL×12 (Special Adapter Models)	0.5 mL×24; 2 mL×24; 2 mL×24; 2 mL×32; 2 mL×48; 2 mL×48; 2 mL×60; 5 mL×12; 10 mL×10; steel can 5mL×6; steel can 15 mL×8; steel can 30 mL×4; steel can 50 mL×2; PTFE 30mL×4; PTFE 50 mL×2; 2 mL×96; 96-well Plate×2
Freezing table	N/A	N/A	N/A	YES
Adapter fixing method	Nut	Nut	Knob cover with safety locking device	Nut
Working time	Run time 0-9999 s; Pause time 0-999 s; Number of runs 1-99
Dimensions	365*265*396mm	370×365×500 mm		650*420*430mm
Screen size	5 inches	5 inches	5 inches	5 inches
Emergency stop button	YES	YES	YES	YES
Electromagnetic safety lock	Screen click control with automatic power-off unlocking. the cover cannot be opened during operation until the grinding program ends, fully protected.
Maximum feeding size	No requirements, adjustable according to the adapter.
Weight	30.7 kg	45 kg	52 kg	54 kg
Power parameters	200-240V AC,50-60 Hz, 200 W	200-240V AC,50-60 Hz, 400 W	200-240V AC,50-60 Hz, 400 W	200-240V AC,50-60 Hz,500 W
Cooling method	Low temperature pre-cooling: adapter can reach -80℃or liquid nitrogen pre-cooling	Compressor cooling	Compressor cooling	Compressor cooling
Transport screws	Yes (2 at the bottom)	Yes (2 at the bottom)	N/A	Yes (2 at the bottom)
Advantages	Small size, cost-effective	Compatible with various adapter specifications. Freezing function, lowest temperature can reach -40℃.	Higher grinding efficiency, reducing tissue degradation.Freezing function, lowest temperature can reach -40℃.	Lower cooling temperature can reach -50℃. low temperature freezing table, Protects samples and meets low-temperature needs for Western Blot experiments, electrophoresis, and transfer membranes.

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Instruments

Homogenizer

Homogenizer

Servicebio is one of the leading manufacturer in China providing FDA & CE approved lab supplies and lab services.

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