Thermo Fisher Scientific Phospho-CaV1.2 (Ser1981) Polyclonal Antibody
Phospho-CaV1.2 (Ser1981) 폴리클로날 항체로 인간, 마우스, 랫트 시료에서 인산화된 CACNA1C 단백질 검출에 적합. Western blot과 IHC(Paraffin) 적용 가능. 고순도 정제된 액상 형태로 안정적이며, 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CACNA1C (Accession Q13936), corresponding to amino acid residues around phosphorylated Ser1981 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817477 |
Product Specific Information
Antibody detects endogenous levels of CACNA1C only when phosphorylated at Ser1981.
Target Information
CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel.
Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization.
The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell.
The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio.
There are multiple isoforms of these proteins, either encoded by different genes or the result of alternative splicing of transcripts.
The protein encoded by CACNA1C binds to and is inhibited by dihydropyridine.
Alternative splicing results in many transcript variants encoding different proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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