Thermo Fisher Scientific Phospho-CDK5 (Ser159) Polyclonal Antibody
CDK5의 Ser159 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC 등 다양한 응용 가능. 고순도 정제 및 안정적 액상 형태로 제공되며, 신경세포 연구에 적합. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human CDK5 (Accession Q00535), corresponding to amino acid residues around phosphorylated Ser159 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817480 |
Product Specific Information
This antibody detects endogenous levels of CDK5 only when phosphorylated at Ser159.
Target Information
CDK5 is a member of the Cyclin-Dependent Kinase family, most abundant in the mammalian brain. The active form, also known as neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein derived from a 35 kDa neuron-specific precursor. CDK5 plays a crucial role in neuronal migration during CNS development and phosphorylates various substrates involved in cellular processes such as adhesion, motility, synaptic plasticity, and drug addiction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-106081_CDK5_Q00535-1_Rabbit.svg, PA5-106081_CDK5_Q00535-1_Rabbit_PDP.jpeg)
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