Thermo Fisher Scientific Phospho-ALOX5 (Ser664) Polyclonal Antibody
Phospho-ALOX5 (Ser664) 항체로 인간, 마우스, 랫트 시료에 반응합니다. Western blot 및 ICC/IF에 적합하며, 인산화된 Ser664 부위의 내인성 5-Lipoxygenase를 특이적으로 검출합니다. 고순도 정제 및 안정한 보관용 버퍼 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ALOX5 (Accession P09917), corresponding to amino acid residues around phosphorylated Ser664 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817473 |
Product Specific Information
This antibody detects endogenous levels of 5-Lipoxygenase only when phosphorylated at Ser664.
Target Information
The ALOX5 gene encodes a protein required for leukotriene synthesis in conjunction with the Arachidonate 5-lipoxygenase-activating protein. Leukotrienes are arachidonic acid metabolites involved in inflammatory responses such as asthma, arthritis, and psoriasis. The protein localizes to the plasma membrane, and inhibitors of its function block translocation of 5-lipoxygenase from the cytoplasm to the membrane, thereby inhibiting activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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