Thermo Fisher Scientific Phospho-Btk (Ser179) Polyclonal Antibody
BTK 단백질의 Ser179 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합. Human, Mouse, Rat 반응성. 고순도 액상 형태로 안정적 보관 가능.
- 카탈로그번호
- PA5106076
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BTK (Accession Q06187), corresponding to amino acid residues around phosphorylated Ser179 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817475 |
Product Specific Information
Antibody detects endogenous levels of BTK only when phosphorylated at Ser179.
Target Information
Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily of tyrosine kinases. Mutations in the BTK gene have been linked to severe developmental blocks in human B-cell ontogeny and immunodeficiency disorders.
BTK interacts with members of the toll-like receptor (TLR) family such as TLR4, TLR6, TLR8, and TLR9. These TLRs are critical molecules in both innate and adaptive immunity and can recognize diverse microbial pathogens.
BTK also interacts with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting its involvement in lipopolysaccharide signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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