Thermo Fisher Scientific Abciximab Chimeric Recombinant Rabbit Monoclonal Antibody (7E3 (Abciximab))
Thermo Fisher Scientific의 Abciximab Chimeric Recombinant Rabbit Monoclonal Antibody (7E3)은 인간 CD41을 특이적으로 인식하는 재조합 단일클론 항체입니다. 혈소판 응집 억제 연구에 적합하며, HEK293 세포에서 발현되고 Protein A로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1 µg/mL
Inhibition Assays (IA)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7E3 (Abciximab) |
| Immunogen | CD41, integrin alpha chain 2b forming a fibrinogen receptor in heterodimeric complex with beta 3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074311 |
Product Specific Information
Specificity: Recognises human CD41.
Target Information
Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. It binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules.
It also binds to the vitronectin (alpha-v-beta-3) receptor found on platelets and vessel wall endothelial and smooth muscle cells.
Abciximab’s binding to the intact platelet GpiIb/IIIa receptor (a member of the integrin family) blocks access of large molecules to the receptor, likely through steric hindrance or conformational changes rather than direct interaction with the RGD binding site.
Additionally, abciximab blocks the Mac-1 receptor on monocytes and neutrophils, inhibiting monocyte adhesion.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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