Thermo Fisher Scientific Gemtuzumab Chimeric Recombinant Rabbit Monoclonal Antibody (hP67.6 (Gemtuzumab))
인간 CD33 항원을 인식하는 재조합 토끼 단클론 항체로, Gemtuzumab(hP67.6) 클론 기반 제품입니다. ICC/IF 및 유세포분석에 적합하며, Protein A로 정제된 액상 형태입니다. 연구용으로만 사용 가능하며, 4°C 단기 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | hP67.6 (Gemtuzumab) |
| Immunogen | Gemtuzumab was generated by humanization of the murine P67.6 clone, raised against CD33-transfected FMY9S5 cells of human origin. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074312 |
Product Specific Information
- Specificity: Recognises human CD33.
Target Information
Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody conjugated with a calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from Micromonospora echinospora ssp. calichensis. Approximately 50% of the antibody is loaded with 4–6 moles of calicheamicin per mole of antibody.
The antibody specifically targets the CD33 antigen expressed on leukemic myeloblasts in most patients with acute myeloid leukemia (AML). By binding to CD33, the cytotoxic agent inhibits tumor cell growth and induces apoptosis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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