Thermo Fisher Scientific CD28 Recombinant Mouse Monoclonal Antibody (JJ316)
쥐 CD28 항원을 인식하는 재조합 마우스 단클론 항체로, T 세포 활성화 및 기능 분석에 적합합니다. 다양한 응용(IHC, ICC/IF, Flow Cytometry 등)에 사용 가능하며, HEK293 세포에서 발현된 IgG1, kappa 형식의 항체입니다. 단백질 A로 정제되어 높은 순도를 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| Functional Assay | Assay-dependent |
| T-Cell Activation (TCA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JJ316 |
| Immunogen | Made by immunizing BALB/c mice with rat CD28 cDNA-transfected A20/J cells. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074313 |
Product Specific Information
Specificity: Recognizes rat CD28 and can trigger T-cell proliferation in vitro and in vivo.
Target Information
CD28 antigen is a 44 kDa disulfide-linked homodimeric T cell-specific surface glycoprotein.
It is a cell adhesion molecule of the immunoglobulin superfamily, constitutively expressed on most peripheral blood T lymphocytes.
CD28 acts as a critical T cell costimulatory receptor, providing the second activation signal by binding CD80 and CD86 expressed by antigen-presenting cells.
It prevents T cells from entering an anergic or apoptotic state and plays a key role in T cell activation.
In murine peripheral lymphoid organs, all CD4+ and CD8+ T cells express CD28, with expression levels varying across thymocyte maturation stages.
Diseases associated with CD28 dysfunction include mycosis fungoides and Sezary’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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