Thermo Fisher Scientific Abciximab Recombinant Human Monoclonal Antibody (7E3 (Abciximab))
인간 CD41을 인식하는 재조합 단클론 항체로, 혈소판 GPIIb/IIIa 수용체에 결합하여 응집을 억제합니다. HEK293 세포에서 발현되었으며, 단백질 A로 정제된 액상 항체입니다. 연구용으로만 사용 가능하며, 4°C 단기 보관 또는 -20°C 장기 보관을 권장합니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Inhibition Assays (IA)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Human / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7E3 (Abciximab) |
| Immunogen | CD41 is the integrin alpha chain 2b forming a fibrinogen receptor in heterodimeric complex with beta 3. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074310 |
Product Specific Information
- Specificity: Recognises human CD41.
Target Information
Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3.
It binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules.
Additionally, it binds to the vitronectin (αvβ3) receptor found on platelets, endothelial, and smooth muscle cells.
Abciximab interferes with the integrin family of adhesion receptors, particularly GPIIb/IIIa, through steric hindrance and conformational changes that block receptor access.
It also blocks the Mac-1 receptor on monocytes and neutrophils, inhibiting monocyte adhesion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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