Thermo Fisher Scientific SMAD1 Polyclonal Antibody
SMAD1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용 가능. Human, Mouse, Non-human primate 반응성. 항원 친화 크로마토그래피로 정제된 고품질 항체.
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Thermo Fisher Scientific SMAD1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | 16 publications |
| Immunohistochemistry (IHC) | - | 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:100 | 1 publication |
| Immunocytochemistry (ICC/IF) | - | 1 publication |
| Immunoprecipitation (IP) | - | 2 publications |
| ChIP assay (ChIP) | - | 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Published Species | Human, Mouse, Xenopus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from an internal region of the human Smad1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533373 |
Target Information
The protein encoded by this gene belongs to the SMAD family, which includes proteins similar to the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins act as signal transducers and transcriptional modulators mediating multiple signaling pathways. SMAD1 mediates bone morphogenetic protein (BMP) signals involved in cell growth, apoptosis, morphogenesis, development, and immune responses. Upon BMP ligand stimulation, SMAD1 is phosphorylated and activated by BMP receptor kinase, forming a complex with SMAD4 for transcription regulation. It is targeted by SMAD-specific E3 ubiquitin ligases (SMURF1 and SMURF2) for ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been identified.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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