Thermo Fisher Scientific PSME1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Proteolytic degradation is essential for maintaining appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, stress response, antigen presentation, receptor modulation, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway degrades most cytosolic and nuclear proteins, while the vacuolar pathway (endosomes, lysosomes, ER) handles others.
The 26S proteasome, an ATP-dependent multisubunit complex (~2.5 MDa), consists of a 20S proteolytic core capped by one or two 19S regulatory complexes. The 19S subunits recognize ubiquitinated proteins, unfold them, and translocate them into the 20S core for degradation.
Defects in this pathway are linked to diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.