Thermo Fisher Scientific PSME1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human PSME1 (PA28-alpha) C-terminal region. Validated for WB, IHC, ICC/IF, and Flow Cytometry. Supplied as liquid at 0.25 mg/mL. For research use only; not for diagnostic applications.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | - |
| Flow Cytometry (Flow) | 3–5 µg/1×10⁶ cells | - |
| Miscellaneous (PubMed) | - | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Raised against the C-terminal region of human PA28-alpha (PSME1, UniProt ID: Q06323-1, antigen length: 249 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2533361 |
Target Information
Proteolytic degradation is essential for maintaining appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, stress response, antigen presentation, receptor modulation, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway degrades most cytosolic and nuclear proteins, while the vacuolar pathway (endosomes, lysosomes, ER) handles others.
The 26S proteasome, an ATP-dependent multisubunit complex (~2.5 MDa), consists of a 20S proteolytic core capped by one or two 19S regulatory complexes. The 19S subunits recognize ubiquitinated proteins, unfold them, and translocate them into the 20S core for degradation.
Defects in this pathway are linked to diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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