Thermo Fisher Scientific IRAK1 Polyclonal Antibody
IRAK1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등 다양한 응용에 사용 가능. C-terminal human IRAK1 유래 합성 펩타이드로 면역화. 연구용으로만 사용되며, 고품질 신호 검출에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the C-terminal region of human IRAK1 (Interleukin 1 receptor-associated kinase 1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2533374 |
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. IRAK1 is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Its association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. IRAK1 can also phosphorylate TIRAP, promoting ubiquitination and degradation, and phosphorylates interferon regulatory factor 7 (IRF7), inducing activation and nuclear translocation. This results in transcriptional activation of type I IFN genes, driving an antiviral state.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: 38-5600_IRAK1_P51617-1_Rabbit.svg, 38-5600_IRAK1_P51617-1_Rabbit_PDP.jpeg)
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