Thermo Fisher Scientific SOCS1 Polyclonal Antibody
SOCS1 단백질을 인식하는 Rabbit Polyclonal 항체로, Human 및 Mouse 시료에 반응합니다. Western blot 및 IHC(Paraffin) 분석에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS(pH 7.4) 용액 형태로 제공되며, -20°C에서 보관합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 7 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20 | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published species | Human, Insect, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Raised against the C-terminal region of human SOCS1 (UniProt ID: O15524-1, antigen length: 211 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533372 |
Target Information
The Suppressor of Cytokine Signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular regulators that modulate immune cell responses to cytokines.
SOCS1 functions by inhibiting JAK tyrosine kinase activity, thereby preventing excessive dendritic cell and T-cell activation.
It also exhibits E3 ubiquitin ligase activity, promoting degradation of target proteins through the proteasome pathway.
Through this mechanism, SOCS1 negatively regulates Toll-like receptor signaling (TLR2 and TLR4) by mediating the degradation of the adaptor protein TIRAP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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