Thermo Fisher Scientific Phospho-CHK1 (Ser345) Monoclonal Antibody (S.48.4)
Phospho-CHK1 (Ser345) 단백질을 검출하는 고특이성 단클론 항체로, Western blot, ICC/IF, Flow cytometry에 적합. Human, Mouse, Rat 등 다양한 종 반응성. 액상 형태로 -20°C 보관. DNA 손상 반응 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 2 publications |
| Immunocytochemistry (ICC/IF) | 1:50 | - |
| Flow Cytometry (Flow) | 1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S.48.4 |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer345 of human Chk1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 37 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10979221 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network. It ensures genomic integrity upon genotoxic stress.
When the G2 or S checkpoint is abrogated by inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and apoptosis, while normal cells remain arrested in G1 phase.
Thus, CHK1 inhibitors can enhance the efficacy of DNA-damaging agents in cancer cells, making Chk1 an attractive therapeutic target, especially since approximately 50% of human cancers are p53-deficient.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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