Thermo Fisher Scientific Phospho-IR/IGF1R beta (Tyr1135, Tyr1136, Tyr1150, Tyr1151) Recombinant Rabbit Monoclonal Antibody (S.326.5)
IGF1R 및 IR의 인산화 타이로신 잔기(Tyr1135/1136/1150/1151)를 인식하는 재조합 토끼 단클론 항체. Western blot에 최적화되어 있으며, 인간, 마우스, 랫트에 반응. 고순도 친화 크로마토그래피 정제 및 -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | Proprietary |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | S.326.5 |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr1135/1136 of human IGF-I receptor ß |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 243 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10982593 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other related tyrosine-phosphorylated tyrosine kinases.
Target Information
Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase widely expressed in many cell types of fetal and postnatal tissues. Receptor autophosphorylation follows binding of IGF-I and IGF-II ligands.
Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, Tyr1136) are the earliest major autophosphorylation sites necessary for kinase activation.
Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation, beginning with phosphorylation at Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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