Thermo Fisher Scientific GNAS Polyclonal Antibody
GNAS 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat에 반응합니다. Western blot 및 IHC(Paraffin)에서 검증되었으며, 항원 친화 크로마토그래피로 정제되었습니다. 농도 1.99 mg/mL, PBS/glycerol buffer에 보관되며 연구용으로 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:1,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 807–1037 of GNAS (Uniprot ID: Q5JWF2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.99 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11154111 |
Product Specific Information
- Recommended positive controls: HepG2, Raji, mouse brain, NIH-3T3, JC, rat brain
- Predicted reactivity:
- Mouse (100%)
- Rat (100%)
- Xenopus laevis (97%)
- Xenopus tropicalis (97%)
- Dog (100%)
- Pig (100%)
- Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly before opening the vial.
Target Information
Mutations in the GNAS gene are associated with several disorders including pseudohypoparathyroidism type 1a and 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseous heteroplasia, polyostotic fibrous dysplasia of bone, and certain pituitary tumors.
This gene exhibits a complex imprinted expression pattern, encoding maternally, paternally, and biallelically expressed proteins derived from alternatively spliced transcripts. Upstream exons are located within differentially methylated regions typical of imprinted genes. The close proximity (14 kb) of oppositely expressed promoter regions is unusual.
An antisense transcript may regulate imprinting in this region. Mutations can result in pseudohypoparathyroidism type 1a with atypical autosomal dominant inheritance requiring maternal transmission for full penetrance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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