Thermo Fisher Scientific SATB2 Recombinant Rabbit Monoclonal Antibody (JM52-44)
SATB2 단백질을 표적하는 재조합 토끼 단클론 항체로, WB, IHC, ICC/IF, Flow Cytometry 등에 사용 가능. 높은 특이성과 민감도, 로트 간 일관성, 동물 유래 성분 없는 제형 제공. 연구용으로만 사용.
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Thermo Fisher Scientific SATB2 Recombinant Rabbit Monoclonal Antibody (JM52-44)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50 |
| Flow Cytometry (Flow) | 1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM52-44 |
| Immunogen | Synthetic peptide within Human SATB2 (aa 238–287) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2810064 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone antibody DNA sequences from immunoreactive rabbits, and individual clones are screened to select optimal candidates for production.
Advantages include:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
SATB2 is a DNA-binding protein that interacts with nuclear matrix or scaffold-associated regions, recognizing the sugar-phosphate backbone of double-stranded DNA. It functions as a transcription factor regulating nuclear gene expression by binding to matrix attachment regions (MARs) and inducing chromatin-loop remodeling.
SATB2 also serves as a docking site for chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) to promoters and enhancers. It is essential for initiating upper-layer neuron-specific genetic programs and repressing deep-layer neuron genes, likely through modulation of BCL11B expression.
Mutations in SATB2 are associated with cleft palate isolated (CPI).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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