Thermo Fisher Scientific DR3 Recombinant Rabbit Monoclonal Antibody (11H6L9)
DR3/TNFRSF25 단백질을 인식하는 recombinant rabbit monoclonal antibody로, Western blot 및 Immunocytochemistry에 적합합니다. 높은 특이성과 일관된 로트 간 재현성을 제공하며, Protein A로 정제된 액상 포맷입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 11H6L9 |
| Immunogen | Peptides corresponding to Human TNFRSF25 (aa 398–414, 29–42) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at −20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2633076 |
Product Specific Information
This antibody is predicted to react with Monkey, Cat, Pig, and Bovine.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the large rabbit immune repertoire
Target Information
DR3/TNFRSF25 is a member of the TNF-receptor superfamily, expressed mainly in lymphocyte-rich tissues. It plays a role in regulating lymphocyte homeostasis, stimulating NF-κB activity, and controlling apoptosis. Signal transduction involves death domain–containing adaptor proteins. Knockout studies suggest its role in eliminating self-reactive T cells in the thymus.
Multiple alternatively spliced transcript variants exist, producing membrane-bound or secreted isoforms. In T-cell activation, full-length membrane-bound isoforms predominate, regulating lymphocyte proliferation.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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