Thermo Fisher Scientific TBK1 Recombinant Rabbit Monoclonal Antibody (10H15L13)

Applications

Western Blot (WB)

• Tested Dilution: 1 µg/mL

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Rat, Bovine, and Dog.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broad immunoreactivity due to large rabbit immune repertoire

Target Information

TBK1 serine/threonine kinase is a member of the IKK family and is involved in NF-kappa B activation and IRF3 signaling. TBK1 acts as a ubiquitous transcription factor and essential mediator of immune and inflammatory gene expression.

NF-KB mediates the expression of numerous genes in response to extracellular stimuli. It is associated with IKB proteins in the cytoplasm, which inhibit NF-KB activity. Phosphorylation of I-KB by IKK complex leads to degradation of I-KB and activation of NF-KB.

The IKK complex includes IKKa, IKK beta, and IKKK. TBK1 (TANK-binding kinase 1), also known as NAK (NF-KB-activating kinase) or T2K, activates IKK beta through direct phosphorylation. TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors. It functions upstream of NIK and the IKK complex and plays a critical role in protecting embryonic liver from apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.