Thermo Fisher Scientific ASK1 Recombinant Rabbit Monoclonal Antibody (12H12L11)
ASK1 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot에 최적화되어 있습니다. 높은 특이성과 재현성을 제공하며, 다양한 종(인간, 마우스, 랫드 등)에 반응합니다. 단백질 A 정제 방식으로 제조되어 일관된 품질을 보장합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 12H12L11 |
| Immunogen | Peptides corresponding to human ASK1 (aa408–aa426, aa580–aa597) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C (avoid freeze/thaw cycles). |
| Shipping Conditions | Wet ice |
| RRID | AB_2723923 |
Product Specific Information
This antibody is predicted to react with Monkey, Dog, Pig, and Bovine.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broad immunoreactivity due to diverse rabbit immune repertoire
Target Information
MAP3K5 (ASK1) is a serine/threonine kinase abundantly expressed in human heart and pancreas. It is activated by various extracellular stimuli such as cytokines, growth factors, and environmental stresses.
ASK1 (Apoptosis Signal-Regulating Kinase 1), also known as MAPKKK5, activates MKK4 and MKK6, which subsequently activate JNK and p38 MAP kinases, respectively. ASK1 is activated by TNFR and Fas signaling through TRAF family members and Daxx. Overexpression of ASK1 induces apoptosis, while catalytically inactive ASK1 inhibits TNF-α-induced apoptosis. ASK1 is expressed in a variety of human and mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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