Thermo Fisher Scientific Phospho-FGFR1 (Tyr154) Polyclonal Antibody
FGFR1 Tyr154 인산화 부위를 인식하는 rabbit polyclonal antibody로, Western blot 및 Immunocytochemistry에 적합합니다. 인간, 마우스, 랫트 시료 반응성을 가지며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FGFR1 (Accession P11362), corresponding to amino acid residues around phosphorylated Tyr154. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2818290 |
Product Specific Information
This antibody detects endogenous levels of FGFR1 only when phosphorylated at Tyrosine 154.
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), which are membrane-spanning tyrosine kinases acting as high-affinity receptors for 17 fibroblast growth factors (FGF1–17). These receptors play key roles in biological processes such as mesoderm induction, cell growth and migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, producing multiple isoforms with distinct expression patterns during embryonic and adult stages. Mutations or defects in FGFR1 are associated with several diseases, including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome. Chromosomal aberrations involving FGFR1 are linked to stem cell myeloproliferative disorders and stem cell leukemia lymphoma syndrome.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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