Thermo Fisher Scientific Phospho-GFAP (Ser38) Polyclonal Antibody
GFAP 단백질의 Ser38 인산화 형태를 특이적으로 검출하는 rabbit polyclonal antibody. Western blot, IHC, ICC/IF에 적합하며 인간, 마우스, 랫트 시료에 반응. 고순도 정제, 안정적인 액상 형태로 연구용에 최적화.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GFAP (Accession P14136), corresponding to amino acid residues around phosphorylated Ser38 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818291 |
Product Specific Information
This antibody detects endogenous levels of GFAP only when phosphorylated at Serine 38.
Target Information
GFAP (Glial fibrillary acidic protein) is a member of the class III intermediate filament protein family. It is specifically expressed in astrocytes and certain astroglia of the central nervous system, satellite cells of peripheral ganglia, and non-myelinating Schwann cells. GFAP serves as a marker for astrocytic cells and is expressed in various brain tumors derived from astrocytic cells. It is also found in lens epithelium, Kupffer cells, some salivary tumor cells, and erythrocytes. GFAP helps distinguish astrocytes from other glial cells during development. Mutations in GFAP cause Alexander disease, a rare astrocytic disorder. Alternative splicing results in multiple isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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