Thermo Fisher Scientific Phospho-FLT3 (Tyr842) Polyclonal Antibody
Phospho-FLT3 (Tyr842) 특이적 폴리클로날 항체로, 인산화된 Flt3/CD135 단백질을 검출. Western blot 및 ICC/IF에 최적화. 인간, 마우스, 랫트 등 다양한 종에 반응. 고순도 정제 및 안정적 액상 형태로 연구용 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FLT3 (Accession P36888), corresponding to amino acid residues around phosphorylated Tyr842 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816641 |
Product Specific Information
Antibody detects endogenous levels of Flt3 / CD135 only when phosphorylated at Tyr842.
Target Information
FLT3 is a tyrosine protein kinase that belongs to the growth factor receptor tyrosine kinase family. Activation occurs through binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, inducing homodimer formation and autophosphorylation. The activated receptor phosphorylates and activates multiple cytoplasmic effector molecules involved in apoptosis, proliferation, and differentiation of hematopoietic cells. Mutations leading to constitutive activation of FLT3 are associated with acute myeloid leukemia and acute lymphoblastic leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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