Thermo Fisher Scientific Phospho-GluR1 (Ser849) Polyclonal Antibody
Phospho-GluR1 (Ser849) 다클론 항체로, 인산화된 GluR1 단백질을 특이적으로 검출. Western blot에 최적화되어 있으며, Human, Mouse, Rat 시료에 반응. 고순도 정제 및 안정한 PBS/glycerol buffer 보존. 연구용으로만 사용 가능.
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Applications and Tested Dilution
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GRIA1 (Accession P42261), corresponding to amino acid residues around phosphorylated Ser849. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816644 |
Product Specific Information
This antibody detects endogenous levels of GluR1 only when phosphorylated at Ser849.
Target Information
GluR1 (glutamate receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of L-glutamate induces a conformational change that opens the cation channel, converting the chemical signal into an electrical impulse. The receptor rapidly desensitizes into a transient inactive state with bound agonist. In the presence of CACNG4, CACNG7, or CACNG8, GluR1 shows resensitization characterized by delayed current accumulation upon continuous glutamate application.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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