Thermo Fisher Scientific Phospho-MYH9 (Ser1943) Polyclonal Antibody
MYH9 단백질의 Ser1943 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합하며, 인간, 생쥐, 랫트 시료에 반응. 고순도 정제 및 안정적인 액상 형태로 연구용에 최적화.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MYH9 (Accession P35579), corresponding to amino acid residues around phosphorylated Ser1943 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816639 |
Product Specific Information
This antibody detects endogenous levels of MYH9 only when phosphorylated at Ser1943.
Target Information
The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton involved in cellular processes such as migration, adhesion, division, and maintenance of cell shape.
It spans over 106 kilobases and includes 41 exons encoding a 1,960-amino-acid protein forming a hexameric complex (two heavy chains, two regulatory light chains, two essential light chains).
Mutations in MYH9 cause autosomal dominant disorders collectively known as MYH9-related diseases (MYH9-RD), including May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome. These are characterized by macrothrombocytopenia and may lead to hearing loss, renal failure, and cataracts.
MYH9 also plays a crucial role in hematopoiesis, maintaining hematopoietic stem and progenitor cell function; loss of MYH9 disrupts normal blood cell formation and can lead to bone marrow failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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