Thermo Fisher Scientific Phospho-MYH9 (Ser1943) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

This antibody detects endogenous levels of MYH9 only when phosphorylated at Ser1943.

Target Information

The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton involved in cellular processes such as migration, adhesion, division, and maintenance of cell shape.
It spans over 106 kilobases and includes 41 exons encoding a 1,960-amino-acid protein forming a hexameric complex (two heavy chains, two regulatory light chains, two essential light chains).

Mutations in MYH9 cause autosomal dominant disorders collectively known as MYH9-related diseases (MYH9-RD), including May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome. These are characterized by macrothrombocytopenia and may lead to hearing loss, renal failure, and cataracts.

MYH9 also plays a crucial role in hematopoiesis, maintaining hematopoietic stem and progenitor cell function; loss of MYH9 disrupts normal blood cell formation and can lead to bone marrow failure.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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