Thermo Fisher Scientific Phospho-VEGF Receptor 2 (Tyr1175) Polyclonal Antibody
VEGFR2의 Tyr1175 인산화 형태를 특이적으로 인식하는 토끼 폴리클로날 항체. Western blot 및 IHC(P)에서 검증됨. 인간, 생쥐, 랫트 반응성. PBS/glycerol 용액 형태로 제공되며, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KDR (Accession P35968), corresponding to amino acid residues around phosphorylated Tyr1175. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816640 |
Product Specific Information
Antibody detects endogenous levels of VEGFR2 only when phosphorylated at Tyr1175.
Target Information
KDR (FLK1, VEGFR2) is a type III receptor tyrosine kinase that binds vascular endothelial growth factor with high affinity. It is expressed early in development by endothelial cell precursors. FLK1 encodes one of the two receptors of VEGF, known as the kinase insert domain receptor. Its signaling and trafficking are regulated by multiple factors including Rab GTPase, P2Y purine nucleotide receptor, integrin αVβ3, and T-cell protein tyrosine phosphatase. Mutations in FLK1 are implicated in infantile capillary hemangiomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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