Thermo Fisher Scientific Phospho-SREBP1 (Ser396) Polyclonal Antibody
SREBP1 단백질의 Ser396 인산화 상태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot에 적합하며 Human, Mouse, Rat 시료에 반응. PBS 기반 용액 형태로 제공되며 -20°C에서 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SREBF1 (Accession P36956), corresponding to amino acid residues around phosphorylated Ser396. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816642 |
Product Specific Information
This antibody detects endogenous levels of SREBP1 only when phosphorylated at Ser396.
Target Information
Sterol regulatory element-binding proteins (SREBPs) are transcription factors belonging to the basic helix-loop-helix leucine zipper family of DNA-binding proteins. Three isoforms exist in mammalian tissues—SREBP-1a, SREBP-1c (ADD1), and SREBP-2—differing in structure, regulation, and function.
SREBPs are synthesized as 120 kDa inactive precursors located in the endoplasmic reticulum membrane. Upon activation, they are transported to the Golgi where proteolytic cleavage produces a mature 60–78 kDa transcriptionally active fragment.
In liver and adipose tissues, SREBPs regulate lipid and cholesterol metabolism by inducing transcription of related genes. SREBP-1 mainly controls triglyceride synthesis, while SREBP-2 is associated with cholesterol synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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