Thermo Fisher Scientific Kir4.1 (KCNJ10) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:800

-

Immunohistochemistry (Frozen) (IHC (F))

1:300

-

Immunocytochemistry (ICC/IF)

1:100

-

Product Specifications

Host/Isotype

Guinea pig / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide corresponding to amino acid residues 356-375 of rat Kir4.1 (Intracellular, C-terminus) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Kir4.1 (KCNJ10),uniProtId:P49655-1,ncbiNodeId:10114,antigenRange:357-375,antigenLength:379,antigenImageFileName:PA5-111798_Kir4.1_KCNJ10_P49655-1_Guinea_pig.svg,antigenImageFileNamePDP:PA5-111798_Kir4.1_KCNJ10_P49655-1_Guinea_pig_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2857207

Product Specific Information

Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Peptide sequence is: (C)KLEESLR EQAEKEGSAL SVR

Homology: Human, mouse amino acid residues are identical.

Target Information

The KIR (for inwardly rectifying potassium channel) family of potassium channels possess a greater tendency to allow potassium to flow into the cell rather than out of it. KIR4.1, also known as Kir1.2, is highly expressed in brain including glial cells, astrocytes and cortical neurons. KIR4.1 is also expressed in myelin-synthesizing oligodendrocytes and is crucial to myelination in the developing nervous system. The gene encoding human KIR4.1 maps to chromosome 1. KIR4.2, also known as Kir1.3, is expressed in kidney, lung, heart, thymus and thyroid during development. The gene encoding human KIR4.2 maps to chromosome 21 in the Down syndrome chromosome region 1, and KIR4.2 may play a role in the pathogenesis of Downs syndrome. KIR5.1 forms functional channels only by coexpression with either KIR4.1 or KIR4.2 in the kidney and pancreas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.