Thermo Fisher Scientific GluR1 (extracellular) Polyclonal Antibody

Thermo Fisher Scientific GluR1 (extracellular) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Reconstitute antibody with 50 µL of double distilled water (DDW).
• The reconstituted solution can be stored at 4°C for up to 1 week.
• For longer storage, aliquot and store at -20°C.
• Avoid multiple freeze-thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Peptide sequence: RTSDSRDHTR VDWKR(C)
Homology: Mouse residues identical; human, pig, dog – 13/14 residues identical.

Target Information

GluR1 (glutamate receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of L-glutamate induces a conformational change that opens the cation channel, converting the chemical signal to an electrical impulse. The receptor desensitizes rapidly and enters a transient inactive state characterized by the presence of a bound agonist. In the presence of CACNG4, CACNG7, or CACNG8, GluR1 shows resensitization, characterized by delayed accumulation of current flux upon continued glutamate application.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.