Thermo Fisher Scientific SCN5A Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Reconstitute antibody with 50 µL of double distilled water (DDW).
The reconstituted solution can be stored at 4°C for up to 1 week.
For longer periods, store small aliquots at -20°C. Avoid repeated freeze-thaw cycles.
Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Peptide sequence: DRLPKSDSED GPRALNQLSC
Homology: Mouse amino acid residues identical; human – 17/19 amino acid residues identical.

Target Information

Scn5a is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit.
It is primarily expressed in cardiac muscle and responsible for the initial upstroke of the action potential in an electrocardiogram.
Defects in Scn5a cause long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease.
Alternative splicing results in several transcript variants encoding different isoforms of Scn5a.

Voltage-gated sodium channels (VGSCs) mediate regenerative cell membrane depolarization and conduct electrical signaling in nerves and muscles.
Scn5a expression is also detected in lymphocytes, glia, and fibroblasts. It mediates voltage-dependent sodium ion permeability of excitable membranes, forming sodium-selective channels that allow Na⁺ ions to pass according to their electrochemical gradient.

Functionally, Scn5a regulates the initial upstroke of the action potential, and channel inactivation is influenced by intracellular calcium levels.
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types.
Scn5a is also expressed at low levels in non-excitable cells, where its physiological role remains unclear.

Diseases associated with SCN5A: Long QT Syndrome-3, Brugada Syndrome 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.