Thermo Fisher Scientific TRPC6 Polyclonal Antibody

Thermo Fisher Scientific TRPC6 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute antibody with 50 µL of double distilled water (DDW).
• Store reconstituted solution at 4°C for up to 1 week.
• For longer storage, aliquot and keep at -20°C. Avoid multiple freeze-thaw cycles.
• Centrifuge antibody preparations before use (10,000 × g, 5 min).

Peptide sequence: (C)RRNESQD YLLMDELG
Homology: Rat identical; human 15/16 amino acid residues identical.

Target Information

Trpc6 forms a receptor-activated calcium channel in the cell membrane. The Trpc6 channel is activated by diacylglycerol (DAG) and operates under a phosphatidylinositol second messenger system. Activation occurs independently of protein kinase C and low intracellular calcium levels.

Defects in the Trpc6 gene cause focal segmental glomerulosclerosis 2 (FSGS2). Trpc6 belongs to the mammalian transient receptor potential (TRP) superfamily, specifically the canonical TRP (TRPC) family. Members of the TRPC family are components of receptor-regulated cation channels activated through PLC-coupled receptors.

The TRPC3/6/7 subfamily can be activated by DAG analogs, suggesting a PLC-related activation mechanism. When expressed in transfected cells, Trpc6 acts as a non-selective, store-independent receptor-activated cation channel. It is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation. Evidence indicates that Trpc6 encodes endogenous DAG-activated receptor-operated cation channels in vivo.

Associated Diseases:

• Glomerulosclerosis, Focal Segmental, 2
• Focal Segmental Glomerulosclerosis

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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