Thermo Fisher Scientific MORF4 Monoclonal Antibody (OTI5F2), TrueMAB
MORF4 단백질을 인식하는 마우스 단클론 항체로, WB 및 IHC(P) 실험에 적합합니다. 인간, 생쥐, 개, 랫트에 반응하며, 동결건조 형태로 제공됩니다. 세포 노화 관련 전사 억제 복합체 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5F2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–255 of human MORF4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Cellular senescence is the terminal non-dividing state that normal cells enter after completing their proliferative potential. Fusions of immortal human cell lines have identified four complementation groups, with Mortality Factor 4 (MORF4) as a key member of a transcription factor-like protein family that reverses the immortal phenotype.
MORF4 localizes to the nucleus and contains helix-loop-helix and leucine zipper motifs, enabling formation of transcriptionally active homo- or heterodimers. It binds to transcription corepressors mSin3A and TLE, suggesting a role in transcriptional repression of genes leading to cellular senescence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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