Thermo Fisher Scientific MORF4 Monoclonal Antibody (OTI5E6), TrueMAB

Applications

• Western Blot (WB): 1:500 dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Cellular senescence refers to the terminal non-dividing state that normal cells enter after their proliferative potential is exhausted. Fusions of immortal human cell lines have categorized them into four complementation groups.
Mortality factor 4 (MORF4) was identified as a key member of a family of transcription factor-like proteins capable of reversing the immortal phenotype. MORF4 localizes to the nucleus and contains transcription factor-like motifs, such as helix-loop-helix and leucine zipper motifs, which may enable formation of transcriptionally active homo- or heterodimers.
MORF4 binds to transcription corepressors mSin3A and TLE, suggesting that these complexes may participate in transcriptional repression of genes involved in cellular senescence.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.