Thermo Fisher Scientific MORF4 Monoclonal Antibody (OTI1B12), TrueMAB

Thermo Fisher Scientific MORF4 Monoclonal Antibody (OTI1B12), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

Cellular senescence is the terminal non-dividing state that normal cells enter after completing their proliferative potential. Fusions of immortal human cell lines have identified four complementation groups, with Mortality factor 4 (MORF4) being the lead member of a transcription factor-like protein family that reverses the immortal phenotype.
MORF4 localizes to the nucleus and contains transcription factor-like motifs such as helix-loop-helix and leucine zipper, enabling formation of transcriptionally active homo- or heterodimers.
It binds to transcription corepressors mSin3A and TLE, suggesting these complexes contribute to transcriptional repression of genes involved in cellular senescence.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.