Thermo Fisher Scientific CD8a Monoclonal Antibody (SK1), APC, eBioscience
인간 CD8a를 인식하는 SK1 모노클론 항체로, APC 형광체가 결합된 제품입니다. Flow Cytometry에 최적화되어 있으며, 5 µL/test로 사용 가능합니다. T 세포 및 NK 세포 식별에 유용하며, 4°C 암소 보관 권장.
- 카탈로그번호
- 17-0087-4x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD8a Monoclonal Antibody (SK1), APC, eBioscience
Applications
- Flow Cytometry (Flow): Tested at 5 µL (0.25 µg)/test
- View 12 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SK1 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1311206 |
Additional Formats
- Alexa Fluor 700
- APC-eFluor 780
- Brilliant UV 805
- Brilliant Violet 650
- eFluor 450
- FITC
- NovaFluor Blue 610-70S
- NovaFluor Blue 660-120S
- NovaFluor Blue 690
- NovaFluor Yellow 730
- NovaFluor Yellow 755
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 702
- Request custom conjugation available
Product Specific Information
Description:
The SK1 monoclonal antibody reacts with the human CD8a molecule, a 32–34 kDa cell surface receptor expressed as CD8α/β heterodimer or CD8α/α homodimer. CD8a is found on thymocytes, mature T cells, and NK cells. It binds MHC class I and associates with p56lck to participate in T-cell development and activation.
Applications Reported:
Suitable for flow cytometric analysis.
Applications Tested:
Pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells.
Recommended use: 5 µL (0.25 µg) per test in a final volume of 100 µL. Cell number: 10⁵–10⁸ cells/test.
Excitation: 633–647 nm
Emission: 660 nm
Laser: Red Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family involved in signal transduction and T cell activation.
CD8 is expressed mainly on T cells as a CD8α/β heterodimer, functioning as a co-receptor for MHC-I molecules. CD8α is essential for MHC-I binding and is also present as CD8α/α homodimers on subsets of T cells, NK cells, monocytes, and dendritic cells.
Binding of MHC-I/peptide complexes recruits Lck, triggering lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are crucial for pathogen and tumor cell clearance. Differentiation of naive CD8⁺ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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