Thermo Fisher Scientific CD127 Monoclonal Antibody (A019D5)
CD127 단백질을 표적으로 하는 인간 반응성 마우스 단클론 항체입니다. IHC(P) 및 Flow Cytometry에 적합하며, 비결합형 액상 형태로 제공됩니다. 단백질 A로 정제되어 안정성이 높고 장기 보관 시 -20°C에서 냉동 보관 가능합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2–10 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 0.5–5 µg/10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A019D5 |
| Immunogen | Recombinant protein of human CD127 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Spleen
- Cellular location: Secreted and membrane
Target Information
CD127 (Interleukin-7, IL-7) is a glycoprotein involved in the regulation of lymphopoiesis. The response of cells to CD127 depends on the presence of the interleukin 7 receptor (IL7R), an alpha/gamma chain heterodimer.
The gamma(c) chain, which also associates with the interleukin-2 receptor, activates signal transduction by the IL7R complex, while the alpha chain determines specific signaling events through association with cytoplasmic molecules.
CD127 promotes proliferation of precursor B cells, thymocytes, T cell progenitors, and mature CD4+ and CD8+ T cells. Dysfunction of CD127 is associated with severe combined immunodeficiency and T cell negative/B cell negative/NK positive severe combined immunodeficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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