Thermo Fisher Scientific CD161 Monoclonal Antibody (HP-3G10)
인간 CD161 단백질을 인식하는 단클론 항체로, IHC(P)와 유세포분석(Flow)에 적합. 마우스 IgG1 형식으로 제작되었으며, 비결합형 액상 제품. NK 및 T세포 표지 연구용으로 사용. 연구용으로만 제공.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2–10 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 0.5–5 µg/10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HP-3G10 |
| Immunogen | A recombinant protein of human CD161 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human PBMC cells
- Cellular location: Membrane
Target Information
KLRB1 (Killer cell lectin like receptor subfamily B, member 1, CD161) protein is a type II membrane protein with an external C terminus. It is expressed by almost all NK cells and a subset of CD3+ T cells. KLRB1 is a homodimeric surface protein (40–44 kDa) that plays an inhibitory role on NK cells. Activation leads to stimulation of acid sphingomyelnase/SMPD1 and increased intracellular ceramide, as well as activation of AKT1/PKB and RPS6KA1/RSK1 kinases, and T cell proliferation by anti-CD3.
KLRB1 acts as a lectin binding to Gal-α(1,3)Gal and N-acetyllactosamine epitopes, and also interacts with CLEC2D/LLT1 as a ligand to inhibit NK cell-mediated cytotoxicity and interferon-γ secretion. The protein contains an extracellular domain with C-type lectin motifs, a transmembrane domain, and a cytoplasmic domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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