Thermo Fisher Scientific Phospho-UBA52 (Ser65) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of ubiquitin only when phosphorylated at Ser65.

Target Information

Ubiquitin is a highly conserved protein essential for targeting cellular proteins for degradation by the 26S proteasome. It is synthesized as a precursor protein, either as polyubiquitin chains or as a single ubiquitin fused to another protein. The UBA52 gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. Upon expression, the protein is post-translationally processed to generate free ubiquitin monomer and ribosomal protein S27a, a component of the 40S ribosomal subunit. S27a belongs to the S27AE family, contains C4-type zinc finger domains, and localizes in the cytoplasm. Pseudogenes derived from this gene exist in the genome. Similarly, ribosomal proteins L40 and S30 are also synthesized as fusion proteins with ubiquitin or ubiquitin-like proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.