Thermo Fisher Scientific PAX2 Recombinant Rabbit Monoclonal Antibody (JJ082-08)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to the larger rabbit immune repertoire

Target Information

The PAX genes are a family of transcription factors active in specific tissues during early embryonic development. Pax family members possess a DNA-binding domain encoded by the paired box, enabling them to regulate genetic programs.
Several pax genes are associated with developmental mutations:

• PAX3: Waardenburg syndrome
• PAX6: Aniridia
• PAX2: Wilms tumor

During embryogenesis, PAX2 is expressed in the developing kidney, particularly in condensing metanephric mesenchyme and early epithelial structures. Expression decreases as the tubular epithelium matures but persists in undifferentiated epithelium of Wilms tumors, correlating with poorly differentiated epithelial cell proliferation. Expression of the Wilms tumor suppressor protein WT1 coincides with down-regulation of PAX2, suggesting WT1 directly represses PAX2 transcription.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.