Thermo Fisher Scientific Phospho-GluR1 (Ser845) Recombinant Rabbit Monoclonal Antibody (JJ2009)
Recombinant rabbit monoclonal antibody specific for phospho-GluR1 (Ser845). Validated for Western blot and flow cytometry. Offers high specificity, lot-to-lot consistency, and animal-origin-free formulation. Suitable for human, mouse, and rat samples.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Flow Cytometry (Flow)
- Tested Dilution: 1:10–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JJ2009 |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Ser845 of Human GluR1 (aa 831–880) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809714 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
GluR1 (glutamate receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of L-glutamate induces a conformational change that opens the cation channel, converting a chemical signal into an electrical impulse. The receptor desensitizes rapidly, entering a transient inactive state. In the presence of CACNG4, CACNG7, or CACNG8, GluR1 shows resensitization characterized by delayed accumulation of current flux upon continued glutamate application.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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